Corrigendum to “Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells” [Cancer Lett. 261 (2) (2008) 226–234]
نویسندگان
چکیده
منابع مشابه
Antitumor activity of G-quadruplex-interactive agent TMPyP4 with photodynamic therapy in ovarian carcinoma cells
The aim of the present study was to investigate the potential effects of photodynamic therapy (PDT) mediated by the cationic porphyrin, 5,10,15,20-tetra-(N-methyl-4-pyridyl)porphine (TMPyP4), on an ovarian carcinoma cell line and the underlying mechanisms by which TMPyP4-PDT exerts its actions. The analysis of cell viability, hematoxylin and eosin staining and flow cytometric apoptosis assays r...
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2-Aminopurine (Ap) modified human telomere sequences were used to monitor the specific complex formation of the G-quadruplex and 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP4).
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The DNA G-quadruplex-binding porphyrin TMPyP4·Cu was found to form efficient hybrid catalysts for DNA-based asymmetric catalysis when bound to DNA G-quadruplexes. Nucleobase substitution experiments using human telomere-derived G-quadruplex sequences suggest binding of the porphyrin on the 3'-face.
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In this study, the expression and functional characterization of CFTR (cystic fibrosis transmembrane regulator) was determined in K562 chronic human leukemia cells. Expression of the CFTR gene product was determined by RT-PCR and confirmed by immunohistochemistry and Western blot analysis. Functional characterization of CFTR Cl- channel activity was conducted with patch-clamp techniques. Forsko...
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The telomerase complex is responsible for telomere maintenance and represents a promising cancer therapeutic target. We describe herein the antitelomerase and antitumor properties of a small-molecule compound designed by computer modeling to interact with and stabilize human G-quadruplex DNA, a structure that may form with telomeric DNA, thereby inhibiting access to telomerase. The 3,6,9-trisub...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2016
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2015.11.004